Arraystar scientists have developed a full range of powerful microarrays for evaluating the global expression levels of LncRNAs in humans, mice, and rats. In 2009, we launched the Arraystar LncRNA Microarray V1.0 - the first commercial microarray for expression profiling of LncRNAs and mRNAs side by side. This ground-breaking microarray made us the industry leader in LncRNA research. Following the popularity of this innovative scientific tool, the Arraystar LncRNA Microarray V2.0 was released in March 2011, quickly becoming our best-selling product and contributing greatly to driving the heightened interest in this intriguing group of non-coding RNAs.

To date, these powerful microarrays have proven themselves to be an invaluable resource in LncRNA research touting many high impact publications. To incorporate rapid scientific advances and new data, Arraystar released our version 4.0 Human , version 3.0 Mouse and version 2.0 Rat LncRNA Expression Microarray in succession, which provide a newly-updated and stringent LncRNA collection, as well as additional non-coding RNAs of interest. In addition, the Arraystar Human LncRNA Microarray V4.0 features an enhancement of our concise and scientific LncRNA subgroup and classification.

Data Sources

Human Database: Composition of the Arraystar Human LncRNA Expression Microarray V4.0

Mouse Database: Composition of the Arraystar Mouse LncRNA Expression Microarray V3.0

Rat Database: Composition of the Arraystar Rat LncRNA Expression Microarray V2.0

Specifications

Human LncRNA Expression Microarray V4.0

Reference

Mouse LncRNA Expression Microarray V3.0

Reference

Rat LncRNA Expression Microarray V2.0

Reference

Arraystar LncRNA Microarrays, with transcript-specific detection for accurate detection of multiple transcript isoforms, are the most sensitive and best technology to profile lncRNA expression, better than RNA-seq for lncRNA profiling as lncRNAs are often at lower abundance.

Human LncRNA Microarray V4.0
• Gold-Standard LncRNAs, Reliable LncRNAs and mRNAs certified with proteins on the same chip. Learn more>

Unlike protein coding genes, publically available lncRNAs are often scantily annotated,partial in scope and scattered in collection. Arraystar maintains high quality proprietary transcriptome and lncRNA databases to extensively collect lncRNAs through our lncRNA discovery pipelines, external data sources, and knowledge-based mining of scientific publications. Arraystar Human LncRNA Microarray V4.0 has a total of 40,173 lncRNAs in two major lncRNA collections, 7,506 for Gold Standard LncRNAs and 32,667 Reliable LncRNAs, from more than 47 Tb worth of RNA-seq data and all major public databases and repositories, such as Refseq, USCS Known Genes, GENCODE, lincRNA catalogs, lncRNAdb, T-UCRs, RNAdb, NRED, and scientific publications.

• Systematic and functional lncRNA annotations and analyses to incorporate advances in lncRNA research and are complete with genomic information, subclassification, and potential regulatory mechanisms, to gain insights into the complex lncRNA biology. LncRNAs associated with biological processes or human diseases are annotated and referenced. Learn more>
• A wealth of information for co-expressional and correlational studies of non-coding regulatory lncRNAs with protein coding mRNAs. Learn more>

Mouse and Rat LncRNA Microarray
• LncRNAs are comprehensively collected from the most updated public transcriptome databases, including RefSeq [1], Ensembl [2],lncRNAdb [3], and landmark publications [4-8].
• LncRNAs from the databases and publications are filtered using a stringent computational pipeline for greater reliability. Learn more>
• LncRNAs are classified into subgroups (Intergenic, Bidirectional, Intronic, Antisense and Sense-overlapping), to aid the identification of any putative functional relationships between LncRNAs and their associated protein-coding genes. Learn more>

Arraystar's specially-designed LncRNA microarrays are available only through our LncRNA microarray service. We provide full-service LncRNA microarray profiling, from sample preparation to in-depth data analysis. Our step-by-step quality controls are designed to ensure you get the most reliable results. Just send us your samples, and we'll do the rest!

Please refer to Sample Submission for details in how to get your project started.

•  RNA isolation (Optional)

•  RNA QC

•  cDNA synthesis

•  Target preparation by labeling with Cy3

•  Array hybridization, washing, and scanning

•  Data extraction, analysis and summarization

Arraystar's experienced scientists have intimate knowledge of the LncRNA microarray platform and are experts in the analysis and interpretation of LncRNA profiling data. This familiarity enables us to employ the most robust methods for normalization and data analysis including subgroup classification.

Table 1.  Differentially expressed LncRNAs screening. Differentially expressed LncRNAs (Fold change>2, p-value<0.05) in Group1 vs Group2. In column "Regulation", "Up" indicates up-regulated, "Down" indicates down-regulated.

Deep data mining and advanced analyses (Fig. 1 and 2, for example) are available to carry you further with the wealth of information generated by the microarrays.

Figure 1. Coding-noncoding interaction Co-expression (CNC) subnetwork of an lncRNA-HEIH in hepatocellular carcinoma.

Figure 2. Lnc-GSET to identify enrichment of lncRNAs in biological functions.

Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators.Yang L, et al. Cell Metabolism, 2016.

Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Canli T, et al. Molecular Psychiatry?, 2016

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. Long J, et al. The Journal of Clinical Investigation,2016

Long Non-coding RNA DILC Represses Self-renewal of Liver Cancer Stem Cells via Inhibiting Autocrine IL-6/STAT3 Axis. X Wang, et al. Journal of Hepatology, 2016

An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles.Li X, et al.Particle and Fibre Toxicology, 2016

Integrative Functional Transcriptomic Analyses Implicate Specific Molecular Pathways in pulmonary toxicity from Exposure to Aluminum Oxide Nanoparticles. Li X, et al.Nanotoxicology,2016

Circulating “lncRNA OTTHUMT00000387022” from Monocytes as a Novel Biomarker for Coronary Artery Disease. Yue Cai, et al. Cardiovascular Research, 2016

Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients. Wang L, et al. Cell Death & Disease, 2016.

Identification of Differentially Expressed Long Non-coding RNAs in Polarized Macrophages. Z Huang, et al. Scientific Reports, 2016

Differentially expressed lncRNAs and mRNAs identified by microarray analysis in GBS patients vs healthy controls. Jing Xu, et al. Scientific Reports, 2016

Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma.Mengge Huang, et al. Oncotarget,2016

Identification of a long non-coding RNA NR_026689 associated with lung carcinogenesis induced by NNK.Wu J, et al.Oncotarget,2016

LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer. Lv M, et al.Oncotarget,2016

Expression profiles of long-noncoding RNAs in cutaneous squamous cell carcinoma. Sand M, et al.Epigenomics, 2016

P-178 YI Expression of Long Non-Coding RNAs in Inflammatory Bowel Disease. C Pothoulakis, et al. Inflammatory Bowel Diseases, 2016

P-177 Altered SHIP1-Protein Degradation in a Subset of IBD Patients. S Fernandes, et al. Inflammatory Bowel Diseases, 2016

A novel long non-coding RNA CYP4B1-PS1-001 regulates proliferation and fibrosis in diabetic nephropathy. Min Wang, et al. Molecular and Cellular Endocrinology, 2016

Integrated long non-coding RNA analyses identify novel regulators of epithelial-mesenchymal transition in the mouse model of pulmonary fibrosis. Hao Sun, et al. Journal of Cellular and Molecular Medicine, 2016

Long-noncoding RNAs in basal cell carcinoma. Michael Sand, et al. Tumor Biology, 2016

Long non-coding RNAs expression profiles in hepatocytes of mice after hematopoietic stem cell transplantation. J Qiao,et al. IUBMB Life, 2016

Genome-wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patientswith.Chen D, et al.Cancer Medicine, 2016

Plasma long noncoding RNA expression profile identified by microarray in patients with Crohn's disease. Chen D, et al. World Journal of Gastroenterology, 2016

Unraveling the Expression Profiles of Long Noncoding RNAs in Rat Cardiac Hypertrophy and Functions of lncRNA BC088254 in Cardiac Hypertrophy Induced by Transverse Aortic Constriction. Li X, et al. Cardiology, 2016

Microarray Analysis of lncRNAs and mRNAs Co-Expression Network and lncRNA Function as ceRNA in Papillary Thyroid Carcinoma. Xie Jing, et al. Journal of Biomaterials and Tissue Engineering, 2016

LncRNA expression profiles reveal the co-expression network in human colorectal carcinoma J Liu, et al.Int J Clin Exp Pathol, 2016

LncRNA uc.48 siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats mediated by P2X7receptor in SCG. Bing Wu, et al. Autonomic Neuroscience, 2016

Reciprocal regulation of long noncoding RNAs THBS4-003 and THBS4 control migration and invasion in prostate cancer cell lines.J Liu,et al. Molecular Medicine Reports,2016

Long noncoding RNA are aberrantly expressed in human papillary thyroid carcinoma.Meiliu Yang,et. al.oncology letters,2016

Long Noncoding RNA Expression Profiling Using Arraystar LncRNA Microarrays. Yanggu Shi, et al. Methods in Molecular Biology, 2016

A Cytoplasmic NF-kB Interacting Long Noncoding RNA Blocks IkB Phosphorylation and Suppresses Breast Cancer Metastatis. Liu B, et al. Cancer Cell, 2015

Role of MYC-Regulated Long Noncoding RNAs in Cell Cycle Regulation and Tumorigenesis. Kim T, et al. J Natl Cancer Inst, 2015

Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/ß-catenin signalling pathway via suppression of activator protein 2a. Ma Y, et al. Gut, 2015

Long Non-coding RNA Fingerprint Regulated by Stretch and Cyclic Strain in Vascular Smooth Muscle Cells: Implications for Aortic Aneurysms. Circulation,2015

Integrated Analysis of the Human Hematopoietic Non-Coding RNA Landscape Reveals Lnc-RNA Stem Cell Signature in AML. Adrian Schwarzer, et al. Blood, 2015.

Long noncoding RNA BC032469, a novel competing endogenous RNA, upregulates hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer. Lü MH, et al. Oncogene, 2015

Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice. A Motterle, et al. Diabetologia, 2015

Expression profile of long non-coding RNAs in pancreatic cancer and their clinical significance as biomarkers. Wang Y, et al. Oncotarget, 2015

Circulation long non-coding RNAs act as biomarkers for predicting tumorigenesis and metastasis in hepatocellular carcinoma. Tang J, et al. Oncotarget,2015

RP5-833A20.1/miR-382-5p/NFIA–Dependent Signal Transduction Pathway Contributes to the Regulation of Cholesterol Homeostasis and Inflammatory Reaction. Hu YW, et al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2015

Genome-wide differential expression of synaptic long noncoding RNAs in autism spectrum disorder. Wang Y, et al. Translational Psychiatry,2015

Long non-coding RNAs as novel expression signatures modulate DNA damage and repair in cadmium toxicology. Zhou Z, et al. Scientific Reports,2015

Microarray Profiling and Co-Expression Network Analysis of LncRNAs and mRNAs in Neonatal Rats Following Hypoxic-ischemic Brain Damage. Zhao F, et al. Scientific Reports, 2015

Distinct Hippocampal Expression Profiles of lncRNAs in Rats Exhibiting a PTSD-like Syndrome. Qingzhen L, et al. Molecular Neurobiology, 2015

Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. Lü M, et al. Cell Death and Disease, 2015

Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence. Glover AR, et al. Endocr Relat Cancer, 2015

Differential Transcriptional Response in Macrophages Infected with Cell Wall Deficient versus Normal Mycobacterium Tuberculosis. Fu YR, et al. Int J Biol Sci, 2015

Circulating lncRNAs associated with occurrence of colorectal cancer progression. Shi J, et al. Am J Cancer Res, 2015

TEM7 (PLXDC1), a key prognostic predictor for resectable gastric cancer, promotes cancer cell migration and invasion. Zhang ZZ, et al. Am J Cancer Res, 2015

Identification of differentially expressed signatures of long non-coding RNAs associated with different metastatic potentials in gastric cancer. W Song, et al. J Gastroenterol, 2015

Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles. X Yuan, et al. Journal of Translational Medicine, 2015

High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal. Ye Y, et al. Journal of Translational Medicine, 2015

The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer. Li Z, et al. Journal of Translational Medicine, 2015

Identification of biomarkers for the detection of early stage lung adenocarcinoma by microarray profiling of long non-coding RNAs. P Wang, et al. Lung Cancer, 2015

Roles of competing endogenous RNAs in gastric cancer. Hu Y, et al. Briefings in Functional Genomics, 2015

Identification of lncRNA expression profile in the spinal cord of mice following spinal nerve ligation-induced neuropathic pain.  Jiang BC, et al. Molecular pain, 2015

A novel long nonocoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Yang Q, et al. Toxicol Appl Pharmacol, 2015

A long non-coding RNA contributes to doxorubicin resistance of osteosarcoma. Zhang CL, et al. Tumor Biology, 2015

lncRNA DANCR suppresses odontoblast-like differentiation of human dental pulp cells by inhibiting wnt/ß-catenin pathway. Chen L, et al. Cell and Tissue Research, 2015

Long Non Coding RNA-UCA1 Contributes to Cardiomyocyte Apoptosis by Suppression of p27 Expression. Liu Y, et al. Celluar Physiology and Biochemistry, 2015

Distinct Expression Profiles of lncRNAs Between Regressive and Mature Scars. Li J, et al. Cellular Physiology and Biochemistry, 2015

The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometria provides new insights into adenomyosis. Zhou C, et al. Molecular BioSystems, 2015

Genome-wide analysis of long noncoding RNA expression profiles in patients with non-alcoholic fatty liver disease. Sun C, et al. IUBMB Life, 2015

A co-expression network analysis reveals lncRNA abnormalities in peripheral blood in early-onset schizophrenia. Ren Y, et al. Progress in Neuro-Psychopharmacology and Biological Psychiatry,2015

LncRNA expression profiles and validation in keloid and normal skin tissue.  Liang X, et al. International journal of oncology, 2015

Lung cancer exosomes initiate global long non-coding RNA changes in mesenchymal stem cells. Wang S, et al. International journal of oncology, 2015

Microarray expression profile analysis of long non-coding RNAs in pancreatic ductal adenocarcinoma. Zhou Y, et al. International journal of oncology, 2015

Increased urothelial cancer associated 1 is associated with tumor proliferation and metastasis and predicts poor prognosis in colorectal cancer. Ni B, et al. International journal of oncology, 2015

Overexpression of Long Non-Coding RNA ZXF2 Promotes Lung Adenocarcinoma Progression Through c-Myc Pathway. Yang ZT, et al. Cell Physiol Biochem,2015

Genome-Wide Microarray Analysis of Long Non-Coding RNAs in Eutopic Secretory Endometrium with Endometriosis.  Wang Y, et al. Cell Physiol Biochem,2015

Long noncoding RNA aberrant expression profiles afer cytoreductive surgery and hyperthermic intraperitoneal chemotherapy of AGC ascertained by microarray analysis. X Zeng, et al. Tumor Biology, 2015

Transcriptome analysis reveals the potential contribution of long noncoding RNAs to brown adipocyte differentiation. You LH, et al. Mol Genet Genomics, 2015

Differential lncRNA expression profiles in brown and white adipose tissues. Chen J, et al. Molecular Genetics and Genomics, 2015

Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. J Pan, et al. Am J Reprod Immunol., 2015

Microarray Expression Analysis for the Paradoxical Roles of Acanthopanax senticosus Harms in Treating a-Synucleinopathies. Li XZ, et al. Phytotherapy Research, 2015

Maternal Style Selectively Shapes Amygdalar Development and Social Behavior in Rats Genetically Prone to High Anxiety. Cohen JLi, et al. Dev Neurosci, 2015

Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. American journal of reproductive immunology, 2015

Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer. P Li, et al. Diagnostic Pathology, 2015

Microarray profiling of bone marrow long non-coding RNA expression in Chinese pediatric acute myeloid leukemia patients. Cao L, et al. Oncology reports, 2015

A pilot study of long noncoding RNA expression profiling by microarray in follicular lymphoma. Pan Y, et al. Gene, 2015

The expression profiling and ontology analysis of noncoding RNAs in peritoneal fibrosis induced by peritoneal dialysis fluid. Liu Y, et al. Gene, 2015

Beta-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of hTERT expression. Z Hu, et al. Anti-Cancer Drugs, 2015

Genomic analysis of drug resistant pancreatic cancer cell ling by combining long non-coding RNA and mRNA expression profling. M Zhou, et al. Int J Clin Exp Pathol, 2015

Identification of LncRNAs/mRNAs related to endometrium function regulated by Homeobox A10 in Ishikawa cells. Lin R, et al. Cell Biol Int, 2015

Long non-coding RNA-GAS5 acts as a tumor suppressor in bladder transitional cell carcinoma via regulation of chemokine (C-C motif) ligand 1 expression. Cao Q, et al. Molecular Medicine Reports, 2015

Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Xiong W, et al. Asian Pac J Cancer Prev., 2015

Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage. B Zheng, et al. Molecular Medicine Reports, 2015

Expression profile of long non-coding RNAs is altered in endometrial cancer. L Yang, et al. Int J Clin Exp Med, 2015

Gene microarray analysis of lncRNA and mRNA expression profiles in patients with hypopharyngeal squamous cell carcinoma. J Zhou, et al. Int J Clin Exp Med, 2015

Expression and clinical significance of long non-coding RNA HNF1A-AS1 in human gastric cancer. Yuan Dang, et al. World Journal of Surgical Oncology, 2015.

Altered long noncoding RNA expression profiles in the myocardium of rats with ischemic heart failure. Gao W, et al. J Cardiovasc Med, 2015

Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia. L Sun, et al. Gemomics Data, 2015

Noncoding RNAs in human intervertebral disc degeneration: An integrated microarray study. X Liu, et al. Gemomics Data, 2015

The genome-wide gene expression profiling to predict competitive endogenous RNA network in hepatocellular cancer. H Peng, et al. Gemomics Data, 2015

LncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals. Z Xing, et al. Cell, 2014

A Long Noncoding RNA Activated by TGF-beta Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma. Yuan JH, et al. Cancer Cell, 2014

A Long Noncoding RNA Transcriptional Regulatory Circuit Drives Thermogenic Adipocyte Differentiation. XY Zhao, et al. Molecular Cell, 2014

NRAV, a Long Noncoding RNA, Modulates Antiviral Responses though Suppression of Interferon-Stimulated Gene Transcription. J Ouyang, et al. Cell Host & Microbe, 2014

The Circulating Long Non-Coding RNA LIPCAR Predicts Survival in Heart Failure Patients. Kumarswamy R, et al. Circ Res, 2014

Expression and prognostic impact of lncRNAs in acute myeloid leukemia. Garzon R, et al. PNAS, 2014

Genome-wide Identification of Long Noncoding RNAs in Rat Models of Cardiovascular and Renal Diseases. K Gopalakrishnan, et al. Hypertension, 2014

A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA. G Guo, et al. Oncogene, 2014

Hypoxia-inducible lncRNA-AK058003 promotes gastric cancer metastasis by targeting gama-synuclein. Wang Y, et al. Neoplasia, 2014

Long non-coding RNA MRUL promoters ABCB1 expression in multidrug-resistant gastric cancer cell sublines. Y Wang, et al. Molecular and Cellular Biology, 2014

The human long noncoding RNA, lnc-IL7R, regulates inflammatory response. Cui H, et al. Eur J Immunol, 2014

A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1alpha in pancreatic ductal adenocarcinoma. YW Sun, et al. British Journal of Cancer, 2014

Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis. Song X, et al. J Cell Mol Med, 2014

Exploring the Wnt Pathway-Associated LncRNAs and Genes Involved in Pancreatic Carcinogenesis. Q Wang, et al. Pharmaceutical Research, 2014

Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients. Fu M, et al. Osteoarthritis and Cartilage, 2014

A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent Signal Transduction Pathway Is Essential for the Regulation of Cholesterol Homeostasis and Inflammatory Reactions. YW Hu, et al. Journal of Lipid Research, 2014

Long noncoding RNA are aberrantly expressed in vivo in the cystic fibrosis bronchial epithelium. Paul J. McKie, et al. The International Journal of Biochemistry & Cell Biology, 2014

Long Non-Coding RNA Profiling in Laryngeal Squamous Cell Carcinoma and Its Clinical Significance:Potential Biomarkers for LSCC. Z Shen, et al. PLoS ONE, 2014

Expression Profiling of RNA Transcripts during Neuronal Maturation and Ischemic Injury. P Kaur, et al. PLoS ONE, 2014

The Long Noncoding RNA Expression Profile of Hepatocellular Carcinoma Identified by Microarray Analysis. J Zhu, et al. PLoS ONE, 2014

Dynamic Transcription of Long Non-Coding RNA Genes during CD4 T Cell Development and Activation. F Xia, et al. PLoS ONE, 2014

Analysis of Altered Microarray Expression Profiles in Proximal Renal Tubular Cells in Response to Calcium Oxalate Monohydrate Crystal Adhesion: Implications for Kidney Stone Disease. Bohan Wang, et al. PLoS ONE, 2014

Expression Pattern of Long Non-coding RNAs in Renal Cell Carcinoma Revealed by Microarray. C Qin, et al. PLoS ONE, 2014

GSTT1 Dletion Is Related to Polycyclic Aromatic Hydrocarbons-Induced DNA Damage and Lymphoma Progression. Fan Yang, et al. PLoS ONE, 2014

Aberrantly Expressed lncRNAs in Primary Varicose Great Saphenous Veins. Xiang Li, et al. PLoS ONE, 2014

Long Noncoding RNAs in spermatogenesis: insights from recent high-throughput transcriptome studies. Luk AC, et al. Reproduction, 2014

Microarray Expression Profile Analysis of Long Non-coding RNAs in Human Gastric Cardiac Adenocarcinoma. Y Wang, et al. Cellular Physiologyand Biochemistry, 2014

lncRNA expression signatures in periodontitis revealed by microarray: The potential role of lncRNAs in periodontitis pathogenesis. Zou Y, et al. J Cell Biochem. 2014

LncRNA-regulated infection and inflammation pathways associated with pregnancy loss genome wide differential expression of lncRNAs in early spontaneous abortion. Wang H, et al. Am J Reprod Immunol, 2014

Genome-wide analysis of long noncoding RNA in primary nasopharyngeal carcinoma by microarray. Yang QQ, et al. Histopathology. 2014

Integrative Analysis of miRNA-mRNA and miRNA-miRNA Interations. Li Guo, et al. BioMed Research International, 2014

The Role of PinX1 in Growth Control of Breast Cancer Cells and Its Potential Molecular Mechanism by mRNA and lncRNA Expression Profiles Screening. R Shi, et al. BioMed Research International, 2014

TF2 LncRNA: Identifying common transcription factors for a list of lncRNA genes from ChIP-Seq data. Q Jiang, et al. BioMed Research International, 2014

Expression of transcribed ultraconserved regions of genome in rat cerebral cortex. SL Mehta, et al. Neurochemistry International, 2014

Screening of lymph nodes metastasis associated lncRNAs in colorectal cancer patients. J Han, et al. World J Gastroenterol, 2014

Long non-coding RNAs expressed in pancreatic ductal adenocarcinoma and lncRNA BC008363 an independent prognostic factor in PDAC. J Li, et al. Pancreatology, 2014

Long noncoding RNA expression in dermal papilla cells contributes to hairy gene regulation. C Lin, et al. Biochemical and Biophysical Research Communications, 2014

Expression profiling of long noncoding RNAs and the dynamic changes of lncRNA-NR024118 and Cdkn1c in angiotensin II-treated cardiac fibroblasts. Xiao-Yang Jiang, et al. Int J Clin Exp Pathol, 2014

Expression profiling and ontology analysis of long noncoding RNAs in post-ischemic heart and their implied roles in ischemia/reperfusion injury. Liu Y, et al. Gene, 2014

Microarray expression profile of long non-coding RNAs in EGFR-TKIs resistance of human non-small cell lung cancer. Cheng NN, et al. Oncology Reports, 2014

Differential Expression of Long Noncoding RNAs in Human Cumulus Cells Related to Embryo Developmental Potential: A Microarray Analysis. Reproductive Sciences, 2014

Low expression of novel lncRNA RP11-462C24.1 suggests a biomarker of poor prognosis in colorectal cancer. D Shi, et al. Medical Oncology, 2014

Microarray expression profile analysis of long non-coding RNAs in human breast cancer: A study of Chinese women. Xu N, et al. Biomedicine &Pharmacotherapy, 2014

Genome-wide analysis of long noncoding RNA signature in human colorectal cancer. Xue Y, et al. Gene, 2014

Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma. L Zhang, et al. Biomedicine & Pharmacotherapy, 2014

Differential Expression Profile of Long Non-coding RNAs during Differentiation of Cardiomyocytes. Shasha Zhu, et al. International Journal of Medical Sciences, 2014

Detection of long-chain non-encoding RNA differential expression in non-small lung cancer by microarray-analysis and preliminary verification. Wang Y, et al. Molecular Medicine Reports, 2014

Microarray analysis of long non-coding RNA expression in human acute rejection biopsy samples following renal transplantation. W Chen, et al. Molecular Medicine Reports, 2014

Use of PET in thyroid malignancies. Rodney hicks. ANZ Journal of Surgery, 2014

Long intergenic non-coding RNA induced by X-ray irradiation regulates DNA damage response signaling in the human bronchial epithelial BEAS-2B cell line. Y Jiao, et al. Oncology Letters, 2014

Genome-wide profiling to analyze the effects of Ox-LDL induced THP-1 macrophage-derived foam cells on gene expression. YW Hu, et al. Genomics Data, 2014

Gene microarray analysis of the lncRNA expression profile in human urothelial carcinoma of the bladder. H Luo. Int J Clin Exp Med, 2014

Repression of the Long Noncoding RNA-LET by Histone Deacetylase 3 Contributes to Hypoxia-Mediated Metastasis. Yang F, et al. Mol Cell, 2013

A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. Guohui Wan, et al. EMBO, 2013

LncRNA Hematlas Defines Blood Lineage-Specific RNA Expression Signatures and Novel LincRNA Biomarkers. Stephan Emmrich, et al. Blood, 2013

LncRNA-LALR1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/beta-Catenin signaling. Xu D, et al. Hepatology, 2013

Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis. Qiang Liu, et al. Arthritis Rheumatism, 2013

LncRNA Pathway Involved in Premature Preterm Rupture of Membrane(PPROM): An Epigenomic Approach to Study the Pathogenesis of Reproductive Disorders. Xiucui Luo, Qingxi Shi, et al. PLoS ONE, 2013

Transcriptome Analysis Reveals Distinct Patterns of Long Noncoding RNAs in Heart and Plasma of Mice with Heart Failure. Danhua Li, et al. PLoS ONE, 2013

Long Non-Coding RNA Expression Profiling of Mouse Testis during Postnatal Development. Jin Sun, et al. PLoS ONE, 2013

Integrated Analysis of Dysregulated lncRNA Expression in Fetal Cardiac Tissues with Ventricular Septal Defect. Guixian Song, et al. PLoS ONE, 2013

The noncoding RNA Expression Profile and the Effect of lncRNA AK126698 on Cisplatin Resistance in Non-Small-Cell Lung Cancer Cell. Yong Yang, et al. PLoS ONE, 2013

Sinomenine Protests against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Adenosine A2A Receptor Signaling. Jun Li, et al. PLoS ONE, 2013

Long Noncoding RNAs Expression Profile of the Developing Mouse Heart. Zhu JG, et al. J Cell Biochem, 2013

Microarray expression profile analysis of long non-coding RNAs of advanced stage human gastric cardia adenocarcinoma. Y. Wang, et al. Molecular Genetics and Genomics, 2013

Distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle. Jun Zhang, et al. Biochemical and Biophysical Research Communications, 2013

Compared Analysis of LncRNA Expression Profiling in pdk1 Gene Knockout Mice at Two Time Points. Liu H, et al. Cell Physiol Biochem, 2013

Long Noncoding RNAs Expression Profile of the Developing Mouse Heart. Jin Gai Zhu, et al. Journal of Cellular Biochemistry, 2013

Increased binding of stroke-induced long noncoding RNAs to the transcriptional corepressors Sin3A and coREST. Ashutosh Dharap, et al. ASN NEURO, 2013

Long non-coding RNA expression profiling in human gastric cancer and its clinical significances. Haojun Song, et al. Journal of Translational Medicine, 2013

Expression profiling of lncRNAs in C3H10T1/2 mesenchymal stem cells undergoing early osteoblast differentiation. Changqing Zuo, et al. Molecular Medicine Reports, 2013

Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells. Hui Yang, et al. Biochemical Pharmacology, 2013

HBx-related lncRNA Dreh inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin. Huang JF, et al. Hepatology, 2012

Long non-coding RNA-MVIH promotes angiogenesis and serves as a predictor for HCC patients' poor recurrence-free survival after hepatectomy. Sheng-xian Yuan, et al. Hepatology, 2012

Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and cdc42 proteins. Song Wang, et al. Journal of Biological Chemistry, 2012

Genome-wide analysis of long noncoding RNA expression in peripheral blood mononuclear cells of uremia patients. Sui W, et al. J. Nephrol, 2012

Altered long noncoding RNA expressions in dorsal root ganglion after rat sciatic nerve injury. Bin Yu, et al. Neuroscience Letters, 2012

Epigenetic activation of the MiR-200 family contributes to H19 mediated metastasis suppression in hepatocellular carcinoma. Ling Zhang, et al. Carcinogenesis, 2012

lncRNA expression signatures in response to enterovirus 71 infection. Zhixin Yin, et al. Biochemical and Biophysical Research Communications, 2012

LncRNAs Expression Signatures of Renal Clear Cell Carcinoma Revealed by Microarray. Gan Yu, et al. PLoS ONE, 2012

Effect of Focal Ischemia on Long Noncoding RNAs. Ashutosh Dharap, et al. Stroke, 2012

Transcriptome analysis of long noncoding RNAs of the nucleus accumbens in cocaine-conditioned mice. Qian Bu, et al. Journal of Neurochemistry, 2012

Aberrant Expression of Long Noncoding RNAs in Autistic Brain. Mark N. Ziats, et al. J Mol Neurosci, 2012

Genome-wide expression changes in a higher state of consciousness. Metka Ravnik-Glavac, et al. Consciousness and Cognition, 2012

LncRNA profile of glioblastoma reveals the potential role of lncRNAs in contributing to glioblastoma pathogenesis. Han L, et al. International Journal of Oncology, 2012

Long non-coding RNA high expressed in hepatocellular carcinoma (lncRNA-HEIH) facilitates tumor growth through enhancer of zeste homolog 2. Yang, F., Zhang L, et al. Hepatology, 2011.

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Braconi, C., T. Kogure, et al. Oncogene, 2011, 1-7

• Best coverage for known functional lncRNAs: well-known LncRNAs characterized for biological functions or human disease association are comprehensively collected from the most updated public databases and landmark publications [Bartonicek et al. 2016, Devaux et al. 2015 ]. Learn more>

Figure 1. Some lncRNAs associated with cancers were collected from Bartonicek et al. 2016. 

Figure 2. Some LncRNAs involved in cardiac pathways were collected from Devaux et al. 2015

• Comprehensive annotations: The LncRNAs that have been associated with diseases including cancers, cardiovascular diseases and neurodegenerative diseases are carefully categorized, annotated and cross-referenced. Learn more>

Tab1. The annotated information includes:
          Transcript ID in public database: [Refseq, Genebank, Ensemble, UCSC...]
          Class based on genomic location: [enhancer, antisense, intergenic, intronic, bidirectional...]
          Target mRNA genes
          Mechanisms: [signal, decoy, scaffold, guide, ceRNA, miRNA sponge, splicing ...]
          Biological functions: [chromatin modification, cell cycle, differentiation, replication, methylation, imprinting, immune, metabolism, senescence...]
          Diseases: [cancers, cardiovascular, neurodegenerative, kidney, diabetes, syndromes...] 

Annotation Example 1 - Cancer-associated lncRNA NBAT-1

Fig 3. Information of NBAT-1 annotated by Arraystar is shown in the green rectangular area.

Annotation Example 2 - LncRNA Mhrt in cardiovascular diseases

Fig4. Information of MHRT annotated by Arraystar is shown in the blue rectangular area.

Annotation Example 3 – LncRNA BACE1-AS in neurodegenerative diseases

Fig5. Information of BACE1-AS annotated by Arraystar is shown in the red rectangular area.

• A powerful tool for biomarker screening and validation: All the primer sets are optimized and fully validated experimentally using numerous sample types, to meet the needs of biomarker discovery.

Figure 2. A snippet of the lncRNAs on the PCR array with published biomarker potentials and utilities.

• Transcript-specific detection: Transcript-specific PCR primers are designed to target the specific exon or splice junction sites, for unambiguous and accurate detection of each individual LncRNA isoforms.

• Most reliable and accurate quantification: Each lncRNA is quantified at high accuracy and data quality, by using a series of external controls (RNA Spike-In, positive PCR control, and Genomic DNA Control) and six internal housekeeping genes. Normalization is performed by geometric means of multiple reference genes selected by experimentally validated algorithm, instead of a single reference gene. 

• Fast and easy: Ready-to-use PCR array in a 384-well plate format. The entire process can be completed in less than 4 hours.